Pyridine → HCID 21090955, compound

HRID 351223Notes

Reaction equation

HRID 351223 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:25]=[CH:24][C:16]([O:17][CH2:18][CH2:19][NH:20][C:21]([NH2:23])=[O:22])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:26]([F:29])([F:28])[F:27])=[N:9]2)=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:36](OC(=O)C)(=[O:38])[CH3:37]>ClCCl>[C:36]([O:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:25]=[CH:24][C:16]([O:17][CH2:18][CH2:19][NH:20][C:21]([NH2:23])=[O:22])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:26]([F:28])([F:29])[F:27])=[N:9]2)=[CH:6][CH:7]=1)(=[O:38])[CH3:37]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 21091035HCID 21091035, compound

Product 1

HCID 21090955HCID 21090955, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of N-(2-{4-[1-(4-hydroxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}ethyl)urea obtained by Example 81 (148.5 mg) in dichloromethane (1.5 ml) was added pyridine (163 μL) and acetic anhydride (45 μL), and the mixture was stirred at room temperature for 1 hr and stirred under reflux for 3 hrs.

Workup

  1. stirringstirred
  2. temperatureunder reflux for 3 hrs

Sources & evidence

ORD record
ord-28a30d553df3442ca1cf777b3eee4b1c
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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