反应详情

A mixture of 4-hydroxypropiophenone (20 g), benzyl chloride (16.1 ml), K2CO3 (12.9 g) and KI (2.21 g) in EtOH (80 ml) and H2O (1 ml) was stirred under reflux condition for 4 hours. The reaction mixture was cooled and filtered. Appeared crystal was dissovled with EtOAc and water. Organic layer was separated and washed with water and brine, dried over MgSO4 and filtered. Filtrate was evaporated under reduced pressure to give 30.0 g (94%) of 1-[4-(benzyloxy)phenyl]-1-propanone as a crystal.

1. temperatureunder reflux condition for 4 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customOrganic layer was separated
5. washwashed with water and brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customFiltrate was evaporated under reduced pressure