Acetic Anhydride → HCID 14300140, compound

HRID 351342Notes

Reaction equation

HRID 351342 reaction equation
[F:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[F:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:12](=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 888852-Fluoro-3-nitroaniline

Product 1

HCID 14300140HCID 14300140, compoundYield 33.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution (233 mL) of 2-fluoro-3-nitroaniline (18.2 g, 116 mol) in pyridine was added acetic anhydride (27.4 mL, 291 mmol) and the mixture was stirrred at room temperature for 16 hrs. The reaction solution was concentrated under reduced pressure and the obtained residue was treated with isopropyl ether to give the title compound (19.2 g) as a powder.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additionthe obtained residue was treated with isopropyl ether

Sources & evidence

ORD record
ord-4d9b022f29b4438780c880c0a1762037
Source dataset
uspto-grants-2007_02
Patent number
US07183415B2

Reaction notes

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