Acetaldehyde → HCID 69036129, compound

HRID 351399Notes

Reaction equation

[CH:1](=O)[CH3:2].C=O.[C:6]1([S:12]([CH2:15][C@@H:16]2[CH2:21][C@H:20]([NH:22][CH:23]([CH3:25])[CH3:24])[CH2:19][CH2:18][C@@H:17]2[N:26]2[CH2:31][CH2:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=3)=[CH:28][C:27]2=[O:42])(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[C:6]1([S:12]([CH2:15][C@@H:16]2[CH2:21][C@H:20]([N:22]([CH:23]([CH3:25])[CH3:24])[CH2:1][CH3:2])[CH2:19][CH2:18][C@@H:17]2[N:26]2[CH2:31][CH2:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:39])[F:40])[CH:33]=3)=[CH:28][C:27]2=[O:42])(=[O:13])=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

Reactant 3

HCID 177Acetaldehyde

HCID 712Formaldehyde

HCID 69035756HCID 69035756, compound

Product 1

HCID 69036129HCID 69036129, compound

Procedure

Following the procedure of Example 104 but substituting acetaldehyde for aqueous formaldehyde, 1-([(1S, 2R, 4R)-2-benzenesulfonylmethyl-4-isopropylamino-cyclohexyl)-4-(3-trifluoromethylphenyl)-5,6-dihydro-1H-pyridin-2-one (43 mg, 0.08 mmol) was converted to the title product (45 mg) as a white glassy solid. MS found: (M+H)+=563.29.

Sources & evidence

ORD record: ord-004d6fcd163441fea53b1a951e87f9b0
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07183270B2

Reaction notes

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