反应详情

To a solution of 1-methyl-3,4-di(4-benzyloxy-phenyl)-cyclohex-3-ene carbaldehyde (200 mg, 0.409 mmol) in MeOH (10.0 mL) at −10° C. was added NaBH4 (100 mg, excess). The reaction mixture was stirred 30 min and then quenched with 51% HCl solution (5 mL), extracted with ethyl acetate (50 mL) and dried over MgSO4. The reaction mixture was then concentrated and purified on SiO2 (50% ethyl acetate/hexane) to yield (1-methyl-3,4-di(4-benzyloxy-phenyl)-cyclohex-3-enyl)-methanol.

1. customquenched with 51% HCl solution (5 mL)
2. extractionextracted with ethyl acetate (50 mL)
3. dry with materialdried over MgSO4
4. concentrationThe reaction mixture was then concentrated
5. custompurified on SiO2 (50% ethyl acetate/hexane)