Sodium borohydride → (1-Methyl-3,4-di(4-benzyloxy-phenyl)-cyclohex-3-enyl)-methanol

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Reaction Steps

To a solution of 1-methyl-3,4-di(4-benzyloxy-phenyl)-cyclohex-3-ene carbaldehyde (200 mg, 0.409 mmol) in MeOH (10.0 mL) at −10° C. was added NaBH4 (100 mg, excess). The reaction mixture was stirred 30 min and then quenched with 51% HCl solution (5 mL), extracted with ethyl acetate (50 mL) and dried over MgSO4. The reaction mixture was then concentrated and purified on SiO2 (50% ethyl acetate/hexane) to yield (1-methyl-3,4-di(4-benzyloxy-phenyl)-cyclohex-3-enyl)-methanol.

Provenance & Evidence