HRID351459

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID96

Acetoacetic acid

C4H6O3

HCID8868

Ethyl acetoacetate

C6H10O3

结构：CCOC(=O)CC(=O)CC(=O)CCn1c(-c2ccc(F)cc2)c(-c2ccccc2)c(C(=O)Nc2ccccc2)c1C(C)C

HCID11330705

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1

HCID6483036

Atorvastatin lactone

C33H33FN2O4

PROCEDURE

实验过程

In a process analogous to Step 5 METHOD A, by substituting the appropriate ester or amide of acetoacetic acid for ethyl acetoacetate, one obtains the following compounds:

WORKUP

后处理

customobtains the following compounds

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-366f902b373f4b91ab431912b2e6de22
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07183408B2
来源说明: uspto-grants-2007_02

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:31][CH2:32][C:33](=O)[CH2:34][C:35](=[O:42])[CH2:36][C:37]([O:39]CC)=[O:38])[C:10]([CH:28]([CH3:30])[CH3:29])=[C:11]([C:19](=[O:27])[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.C(O)(=O)CC(C)=O.C(OCC)(=O)CC(C)=O>>[C:21]1([NH:20][C:19]([C:11]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:9]([CH2:31][CH2:32][C@@H:33]3[CH2:34][C@@H:35]([OH:42])[CH2:36][C:37](=[O:39])[O:38]3)[C:10]=2[CH:28]([CH3:30])[CH3:29])=[O:27])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1