Hydrochloric Acid → HCID 22957173, compound

HRID 351472Notes

Reaction equation

C(OC(=O)[NH:7][C:8]([C:11](=[O:48])[NH:12][C@@H:13]([C:23]([N:25]1[CH2:30][CH2:29][N:28]2[C:31](=[O:40])[N:32]([CH2:35][C:36]([F:39])([F:38])[F:37])[C:33](=[O:34])[C@:27]2([CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][N:43]=2)[CH2:26]1)=[O:24])[CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([CH3:10])[CH3:9])(C)(C)C.[ClH:50]>CCO>[ClH:50].[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C@@H:13]([C:23]([N:25]1[CH2:30][CH2:29][N:28]2[C:31](=[O:40])[N:32]([CH2:35][C:36]([F:37])([F:38])[F:39])[C:33](=[O:34])[C@:27]2([CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][N:43]=2)[CH2:26]1)=[O:24])[CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:48]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of the compound of Example 199, Step D (73 mg) in EtOH (5 mL, 0° C.) was added conc. HCl (0.5 mL). The solution was stirred at 0° C. for 1 h and concentrated down to deliver 68 mg of Example 199, Step E:+APcl MS (M+1)+ 589; 1H NMR=400 MHz (CD3OD) δ: 8.36 (d, 1H), 4.86 (br m, 3H), 1.44 (s, 3H), 1.42 (s, 3H).

Workup

concentrationconcentrated down

Sources & evidence

ORD record: ord-f6d34c641b1243a29109d6ee9583ad21
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE038524E1

Reaction notes

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