Hydrochloric Acid → HCID 22957171, compound

HRID 351479Notes

Reaction equation

HRID 351479 reaction equation
C(OC(=O)[NH:7][C:8]([C:11](=[O:42])[NH:12][C@H:13]([CH2:33][O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:14](=[O:32])[N:15]1[CH2:20][CH2:19][N:18]2[C:21](=[O:24])[CH2:22][CH2:23][C:17]2([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)[CH2:16]1)([CH3:10])[CH3:9])(C)(C)C.Cl>CCOCC>[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C@H:13]([CH2:33][O:34][CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:14](=[O:32])[N:15]1[CH2:20][CH2:19][N:18]2[C:21](=[O:24])[CH2:22][CH2:23][C:17]2([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)[CH2:16]1)=[O:42]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57147632HCID 57147632, compound

Product 1

HCID 22957171HCID 22957171, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Compound of Example 202, Step E (12 mg, 0.020 mmol) was deprotected as described in General Procedure C to provide, after trituration with ether, Example 202, Step F as its HCl salt (5 mg, 50%): +APcl MS (M+1)+ 494; 1H NMR (400 MHz, CD3OD) δ: 8.90-7.15 (arom series of m, 9 H), 5.31 (m, 0.5H), 5.15 (m, 0.5H), 2.86 (d, 0.5H), 2.77 (d, 0.5H), 1.60 (Me, M, 6H).

Workup

  1. customto provide

Sources & evidence

ORD record
ord-5b39258f65974c0da0e1aba5d2595906
Source dataset
uspto-grants-2004_06
Patent number
USRE038524E1

Reaction notes

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