Isopropanol → 2-Propyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxvpropanoate

HRID 351495Notes

Reaction equation

HRID 351495 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][CH:24](O)[CH3:25]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([O:19][CH:24]([CH3:25])[CH3:23])=[O:18])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 109245703-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

Product 1

HCID 727814342-Propyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxvpropanoate

Procedure

The ester can be prepared by acid catalysed esterification of 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid with/in 2-propanol. Isocratic HPLC method 2 (4.96 min.): 98.4%.

Workup

  1. customIsocratic HPLC method 2 (4.96 min.)

Sources & evidence

ORD record
ord-ad9169e8bcd5447abb22c25ccec53ba6
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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