3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid → Hexyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate

HRID 351496Notes

Reaction equation

HRID 351496 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)CCCCC>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([O:19][CH2:6][CH2:7][CH2:2][CH2:3][CH2:4][CH3:5])=[O:18])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 109245703-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

Product 1

HCID 86587053Hexyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate

Reagents, catalysts & solvents 1

HCID 81031-HexanolSolvent

Procedure

The ester can be prepared by acid catalysed esterification of 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid with/in 1-hexanol. Isocratic HPLC method 2 (8.57 min.): 92.2%.

Workup

  1. customIsocratic HPLC method 2 (8.57 min.)

Sources & evidence

ORD record
ord-8f3c1206b17c425c9a3b1bd5850a3ae3
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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