1-Decanol → HCID 86587064, compound

HRID 351523Notes

Reaction equation

HRID 351523 reaction equation
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2].[CH2:18](O)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]CC>CCCCCCC>[CH2:1]([O:3][C@@H:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[C:5]([O:7][CH2:8][CH2:9][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:6])[CH3:2].[CH2:1]([O:3][C@H:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 81741-DecanolHCID 11791243Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

Product 1

HCID 86587064HCID 86587064, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

Ethyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)propanoate (5 mg) was added to a solution containing Mucor miehei lipase Lipozym IM (immobilised Mucor miehei lipase commercially available from Novo Nordisk) (10 mg), n-decanol 8 μl, heptane 0.5 ml and 4 Å molecular sieves. The reaction mixture was shaken at room temperature and analysed at different times. The reaction mixtures were analysed by the gradient HPLC method 2 and by the chiral HPLC method 4.

Workup

  1. additioncontaining Mucor miehei lipase Lipozym IM (
  2. customThe reaction mixtures

Sources & evidence

ORD record
ord-0d33af6a74d14e1da2f5c9581a2bb37b
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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