反应详情

A solution of 1-(4-methoxycarbonylphenyl)-4-(4-n-pentyloxyphenyl)butane-1,4-dione (765 mg) and p-toluenesulfonic acid monohydrate (8 mg) in toluene (10 ml) was refluxed for 6 hours. The reaction mixture was diluted with dichloromethane, washed with water and brine, and dried over magnesium sulfate. The solvents were removed under reduced pressure and the precipitate was triturated with methanol, collected by filtration, washed with methanol and dried under reduced pressure to give methyl 4-[5-(4-n-pentyloxyphenyl)furan-2-yl]benzoate (665 mg).

1. washwashed with water and brine
2. dry with materialdried over magnesium sulfate
3. customThe solvents were removed under reduced pressure
4. customthe precipitate was triturated with methanol
5. filtrationcollected by filtration
6. washwashed with methanol
7. customdried under reduced pressure