HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]-benzonitrile | HCID 11079003 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride | HCID 69818033 | — |
Reaction Steps
A solution of 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]-benzonitrile (0.582 g) in the mixture of conc. HCl (5.8 ml) and acetic acid (2.9 ml) was refluxed for 3 hours. The reaction mixture was pulverized with water (25 ml). The precipitate was collected by filtration to give 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride (0.51 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743776B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-d13281aaa4fb4e4788caa94125304e34 |
| Source note | uspto-grants-2004_06 |