Acetic Acid → 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride

HRID 351549Notes

Reaction equation

HRID 351549 reaction equation
[CH2:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:27]=[CH:26]C(C#N)=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[ClH:28].[C:29]([OH:32])(=[O:31])[CH3:30]>O>[ClH:28].[CH2:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:27]=[CH:26][C:30]([C:29]([OH:32])=[O:31])=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 110790034-[4-(4-Hexyloxyphenyl)piperazin-1-yl]-benzonitrile

Product 1

HCID 698180334-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]-benzonitrile (0.582 g) in the mixture of conc. HCl (5.8 ml) and acetic acid (2.9 ml) was refluxed for 3 hours. The reaction mixture was pulverized with water (25 ml). The precipitate was collected by filtration to give 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride (0.51 g).

Workup

  1. temperaturewas refluxed for 3 hours
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-d13281aaa4fb4e4788caa94125304e34
Source dataset
uspto-grants-2004_06
Patent number
US06743776B2

Reaction notes

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