反应详情

To the solution of 2-chloro-6-methoxy-3-nitropyridine (5 g) and 6-aminoindazole (3.9 g) in methanol (60 ml) was added triethylamine (4.1 ml), and then the solution was reacted at 55-60° C. for 14 hr. The reaction mixture was cooled at room temperature, added H2O 30 mi slowly at 25° C., and then stirred for 0.5 hr. The reaction mixture was filtered, washed with 50% aqueous methanol solution (15 ml) and obtained a solid product. The solid product was dried at 50° C. in vacuo to obtain the desired compound (6.8 g, 90%).

1. customthe solution was reacted at 55-60° C. for 14 hr
2. filtrationThe reaction mixture was filtered
3. washwashed with 50% aqueous methanol solution (15 ml)
4. customobtained a solid product
5. customThe solid product was dried at 50° C. in vacuo