反应详情

A mixture of 1.99 g of 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile, 0.59 g of potassium cyanide and 20 ml of allyl alcohol is stirred at room temperature for 20 hours and thereafter the allyl alcohol is distilled off. The residue is poured onto ice/water and extracted with methylene chloride, and the combined extracts are washed with water, dried over anhydrous sodium sulphate and evaporated. After flash chromatography on silica gel (elutent: ethyl acetate) there is obtained pure allyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-carboximidate as an oil.

1. distillationthe allyl alcohol is distilled off
2. additionThe residue is poured onto ice/water
3. extractionextracted with methylene chloride
4. washthe combined extracts are washed with water
5. dry with materialdried over anhydrous sodium sulphate
6. customevaporated