Sodium Hydroxide → HCID 22713560, compound

HRID 351632Notes

Reaction equation

HRID 351632 reaction equation
C([O:3][C:4](=[O:19])[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[NH:18])[NH2:17])=[CH:12][CH:11]=1)=[O:8])C.[OH-].[Na+]>C(O)C>[C:16]([C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:7](=[O:8])[NH:6][CH2:5][C:4]([OH:19])=[O:3])=[CH:15][CH:14]=1)(=[NH:17])[NH2:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15521690HCID 15521690, compound

Product 1

HCID 22713560HCID 22713560, compoundYield 113.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-[3-(4-carbamimidoylphenyl)ureido]acetic acid ethyl ester (24.48 g, 0.0926 mol, compound of example 3c) in ethanol (100 ml) and NaOH (3.705 g, 0.0926 mol, in 5 ml water) was stirred for 22 h at room temperature. The precipitate was filtered off and washed with ethanol to give 24.78 g of the title compound. MS 258.2 (M)+

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-e723ce618a7b47ea87d22b3b969162fa
Source dataset
uspto-grants-2004_06
Patent number
US06743790B2

Reaction notes

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