HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline → HCID 22626613, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester | HCID 10987983 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 22626613 | HCID 22626613 | 24.9% |
Reaction Steps
3.14 g of 1-tert-butoxycarbonyl-4-acetyl-piperidine and 1.83 g of 2-amino-3-formyl-pyridine were refluxed with 0.25 g of L-proline in n-butanol for 72 hours. After removing the solvent in vacuo the residue was combined with the residue obtained in an identical reaction and chromatographed on silica gel with ethyl acetate/n-heptane (1:1) to give 1.08 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743800B1 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-c07c0ab157704ac0969a79d74be51adb |
| Source note | uspto-grants-2004_06 |