反应详情

3.14 g of 1-tert-butoxycarbonyl-4-acetyl-piperidine and 1.83 g of 2-amino-3-formyl-pyridine were refluxed with 0.25 g of L-proline in n-butanol for 72 hours. After removing the solvent in vacuo the residue was combined with the residue obtained in an identical reaction and chromatographed on silica gel with ethyl acetate/n-heptane (1:1) to give 1.08 g of the title compound.

1. customAfter removing the solvent in vacuo the residue
2. customobtained in an identical reaction
3. customchromatographed on silica gel with ethyl acetate/n-heptane (1:1)