反应详情

219 mg of the compound of step d) were dissolved in 12 ml of dichloromethane and 2 ml trifluoroacetic acid were added under stirring at ambient temperature. After 6 hours the reaction was complete. The solvents were removed in vacuo. The residue was mixed with toluene and this mixture was again evaporated. The resulting resin was triturated with diethylether. After filtration 210 mg of a faint yellow solid were isolated. MS (ES+): m/e=557.2 (M+H)+.

1. customThe solvents were removed in vacuo
2. additionThe residue was mixed with toluene
3. customthis mixture was again evaporated
4. customThe resulting resin was triturated with diethylether
5. filtrationAfter filtration 210 mg of a faint yellow solid
6. customwere isolated