反应详情

5 g (34.0 mmol) of isatin, 4 ml (40.8 mmol) of 2-acetylfuran and 6.3 g (112.2 mmol) of potassium hydroxide were dissolved in 40.9 ml of abs. EtOH and the slurry heated at 80° C. for 12 hours. After cooling of the reaction mixture, 50 ml of water were added and the solution extracted with 50 ml of Et2O. The ice-cooled aqueous phase was acidified to pH 1 with 37% HCl and the precipitate collected by filtration and washed with water. The crude product obtained was dried in-vacuo at 40° C. to yield 8.5 g of the title compound.

1. additionwere added
2. extractionthe solution extracted with 50 ml of Et2O
3. temperatureThe ice-cooled aqueous phase
4. filtrationthe precipitate collected by filtration
5. washwashed with water
6. customThe crude product obtained
7. customwas dried in-vacuo at 40° C.