n-Isopropyl-1-[3-(trimethylsilylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide → 2-(6-Ethynylpyridin-3-yl)propan-2-ol

HRID 351746Notes

Reaction equation

HRID 351746 reaction equation
[OH:1][C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][Si](C)(C)C)=[N:9][CH:10]=1)([CH3:4])[CH3:3].C(NC(C1C(=O)C2C(=NC=CC=2)N(C2C=CC=C(C#C[Si](C)(C)C)C=2)C=1)=O)(C)C>>[C:11]([C:8]1[CH:7]=[CH:6][C:5]([C:2]([OH:1])([CH3:3])[CH3:4])=[CH:10][N:9]=1)#[CH:12]

Participants

3

Reactant 2

HCID 22714290n-Isopropyl-1-[3-(trimethylsilylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamideHCID 227142995-(1-Hydroxy-1-methylethyl)-2-[(trimethylsilyl)ethynyl]pyridine

Product 1

HCID 227142962-(6-Ethynylpyridin-3-yl)propan-2-ol

Procedure

Following the procedure of Step 2 of EXAMPLE 5, but substituting the product 5-(1-hydroxy-1-methylethyl)-2-[(trimethylsilyl)ethynyl]pyridine from present Step 2 for N-isopropyl-1-[3-(trimethylsilylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide, the 2-ethynyl-5-(1-hydroxy-1-methylethyl)pyridine compound was obtained.

Sources & evidence

ORD record
ord-40c2f292567c4d3483f2f4e1a8f78178
Source dataset
uspto-grants-2004_06
Patent number
US06743802B2

Reaction notes

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