反应详情

温度

-10 °C

To a solution of 2-acetyl-5-bromothiophene in THF (2.5 mL/mmol) at −30° C. was added 1.4M methylmagnesium bromide in 3:1 toluene-THF (1.5 eq) and the resulting mixture was warmed to −10° C. and stirred for 1.5 hours. After quenching with saturated aqueous ammonium chloride solution, the mixture was partitioned between ether and water. The organic fraction was dried and evaporated, and the crude material was chromatographed on silica gel eluting with a 1:4 mixture of ether and hexane to afford the 2-bromo-5-(1-hydroxy-1-methylethyl)thiophene compound.

1. customAfter quenching with saturated aqueous ammonium chloride solution
2. customthe mixture was partitioned between ether and water
3. customThe organic fraction was dried
4. customevaporated
5. customthe crude material was chromatographed on silica gel eluting with a 1:4 mixture of ether and hexane