反应详情

温度

120 °C

A mixture of 1.95 g of 6,7-dihydro-5H-dibenz[c,e]azepine and 3 g of urea is stirred at 120° C. for 15 minutes and then poured onto ice/water. After extracting the resulting aqueous mixture with methylene chloride the combined extracts are washed with water, dried over anhydrous sodium sulphate and evaporated. The solid residue is recrystallized from n-hexane/ethyl acetate, and in this manner there is obtained pure 5,7-dihydro-6H-dibenz[c,e]azepine-6-carboxamide, m.p. 212°-214° C.

1. additionpoured onto ice/water
2. extractionAfter extracting the resulting aqueous mixture with methylene chloride the combined extracts
3. washare washed with water
4. dry with materialdried over anhydrous sodium sulphate
5. customevaporated
6. customThe solid residue is recrystallized from n-hexane/ethyl acetate