反应详情

A mixture of interm. (5-e) (43 g) in HCl (3N, 400 ml) and methanol (150 ml) was stirred and refluxed overnight. The mixture was cooled and filtered off. The precipitate was washed with water and diethyl ether and dried. The product was used without further purification, yielding 27 g (94%) of 6-(4-chlorobenzoyl)-4-(3-methoxyphenyl)-2(1H)-quinolinone (interm. 5-f).

1. additionA mixture of interm
2. temperaturerefluxed overnight
3. temperatureThe mixture was cooled
4. filtrationfiltered off
5. washThe precipitate was washed with water and diethyl ether
6. customdried
7. customThe product was used without further purification