4-(Methylsulfonyl)aniline → HCID 10881660, compound

HRID 351822Notes

Reaction equation

HRID 351822 reaction equation
[CH3:1][S:2]([C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH:12]([O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH:12]([O:15][C:16]1[CH:17]=[CH:18][C:19]([CH:20]=[N:9][C:8]2[CH:10]=[CH:11][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=2)=[CH:22][CH:23]=1)([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 796174-(Methylsulfonyl)anilineHCID 2500774-Isopropoxybenzaldehyde

Product 1

HCID 10881660HCID 10881660, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1.04 g (6.09 mmol) of 4-methylsulfonylaniline (obtained in reference example 1), 1.00 mL (6.09 mmol) of 4-isopropoxybenzaldehyde (obtained in reference example 3) and 25 mL of toluene was heated at reflux in a Dean-Stark for 2 days. The solvent was removed and the crude product obtained was directly used in the next reaction.

Workup

  1. temperaturewas heated
  2. temperatureat reflux in a Dean-Stark for 2 days
  3. customThe solvent was removed

Sources & evidence

ORD record
ord-20e480c20fc7491b9b4b97c165a31d95
Source dataset
uspto-grants-2004_06
Patent number
US06743816B2

Reaction notes

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