Acetyl chloride → HCID 15599411, compound

HRID 35184Notes

Reaction equation

HRID 35184 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]3[CH:12]([CH3:18])[CH2:13][C:14](=[O:17])[NH:15][N:16]=3)=[CH:10][C:5]=2[NH:4][CH2:3][CH2:2]1.[C:19](Cl)(=[O:21])[CH3:20]>O1CCCC1>[C:19]([N:4]1[C:5]2[CH:10]=[C:9]([C:11]3[CH:12]([CH3:18])[CH2:13][C:14](=[O:17])[NH:15][N:16]=3)[CH:8]=[CH:7][C:6]=2[O:1][CH2:2][CH2:3]1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 155994106-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one

Product 1

HCID 15599411HCID 15599411, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one was suspended in tetrahydrofuran and one equivalent of acetyl chloride was added. After one half hour at 0° C., the solvent was removed in vacuo, and the product was crystallized from ethanol in 61% yield, mp 185.5°-186° C.

Workup

  1. waitAfter one half hour at 0° C.
  2. customthe solvent was removed in vacuo
  3. customthe product was crystallized from ethanol in 61% yield, mp 185.5°-186° C.

Sources & evidence

ORD record
ord-e25a34daaec2452f894c1a453f000dfd
Source dataset
uspto-grants-1988_08
Patent number
US04766118

Reaction notes

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