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HRID351886

反应详情

EQUATION

反应方程式

HRID 351886 的结构方程式

REACTANTS

反应物

2
结构：CCSC(C)=S
HCID70093

Ethyl dithioacetate

C4H8S2

结构：CS(=O)c1ccc(N2C[C@H](CN)OC2=O)cc1F
HCID22966200

未命名化合物

PRODUCTS

生成物

1
结构：CC(=S)NC[C@H]1CN(c2ccc(S(C)=O)c(F)c2)C(=O)O1
HCID9949404

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to the Method A of General Methods of Preparation of 5-(S)-Thioamidomethyloxazolidinones (Example 1) from 5-(S)-aminomethyl-3-[4′-methylsulfinyl-3′-fluorophenyl]oxazolidine-2-one (0.050 g, 0.184 mmol) and ethyl dithioacetate. Reaction was performed in DMF overnight. Yield 0.058 g (96%). M.p 158-60° C. MS (m/z): [M+H]+=331.

WORKUP

后处理

  1. customReaction
  2. customM.p 158-60° C