Hydrochloric Acid → HCID 15549287, compound

HRID 351928Notes

Reaction equation

HRID 351928 reaction equation
[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]4[NH:29][CH:30]=[CH:31][N:32]=4)=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>O1CCOCC1>[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]4[NH:32][CH:31]=[CH:30][N:29]=4)=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15549286HCID 15549286, compound

Product 1

HCID 15549287HCID 15549287, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

25 mg (0.058 mmol) of 10 are stirred at 70° C. for 36 hours in 1 ml of dioxane together with 0.3 ml of 1N HCl (0.3 mmol), giving 3-phenyl-3-{6-[3-(imidazol-2-ylamino)propoxy]indol-3-yl}propionic acid. Preparative HPLC gives 3-phenyl-3-{6-[3-(imidazol-2-ylamino)propoxy]indol-3-yl}propionic acid trifluoroacetate.

Sources & evidence

ORD record
ord-a1c15b6d0d3c4795b575977d3cfd6721
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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