HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 3-phenyl-3-(6-carboxymethoxyindol-3-yl)propionate trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl 3-phenyl-3-[6-(tert-butoxycarbonylmethoxy)indol-3-yl]propionate | HCID 22714448 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-phenyl-3-(6-carboxymethoxyindol-3-yl)propionate trifluoroacetate | HCID 22714548 | — |
Reaction Steps
1 g (2.36 mmol) of 18 are dissolved in 20 ml of dichloromethane and stirred at room temperature for 20 hours with 2 ml of trifluoroacetic acid. The solution is subsequently evaporated, and the residue is purified by preparative HPLC on RP-18, giving ethyl 3-phenyl-3-(6-carboxymethoxyindol-3-yl)-propionate trifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743810B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-6f1e819255f14c5db31ddb66cb5e3856 |
| Source note | uspto-grants-2004_06 |