Hydrochloric Acid → HCID 22714479, compound

HRID 351936Notes

Reaction equation

HRID 351936 reaction equation
[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>[Pd]>[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]4[CH2:33][CH2:32][CH2:31][CH2:30][N:29]=4)=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15549284HCID 15549284, compound

Product 1

HCID 22714479HCID 22714479, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In accordance with Example 19, 200 mg of ethyl 3-phenyl-3-{6-[3-(pyridin-2-ylamino)propoxy]indol-3-yl}propionate 7 are hydrogenated in the presence of 2N hydrochloric acid and palladium/activated carbon (10%) to give 41.

Sources & evidence

ORD record
ord-fdfcf9ab01574771ae1b8c787b3789b9
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

Loading…