Hydrochloric Acid → HCID 69869507, compound

HRID 351939Notes

Reaction equation

HRID 351939 reaction equation
[C:1]1([C@@H:7]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>O1CCOCC1>[ClH:32].[C:1]1([C@@H:7]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH2:22][CH2:23][CH2:24][NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11486828HCID 11486828, compound

Product 1

HCID 69869507HCID 69869507, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2 g (4.8 mmol) of the internal salt 46 are dissolved in 5 ml of dioxane and stirred for 2 hours at RT with 20 ml (20 mmol) of 1N HCl. The solution is subsequently freeze-dried, giving (3S)-3-phenyl-3-{6-[3-(pyrid in-2-ylamino)propoxy]indol-3-yl}propionic acid hydrochloride.

Workup

  1. customThe solution is subsequently freeze-dried

Sources & evidence

ORD record
ord-85b32c7d4c7f403190d0bedd9ddb99a4
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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