Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride → 2-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

HRID 35195Notes

Reaction equation

HRID 35195 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([O:21]C)=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1>Cl>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1

Participants

3

Reactant 1

HCID 21295725Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride

Product 1

HCID 704078322-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 205 mg of methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride in 15 ml of 6N hydrochloric acid was refluxed for 18 hours. The solution was cooled to room temperature and the precipitate filtered off, washed with cold 6N hydrochloric acid followed by acetone and air dried to give 2-(3-pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride, m.p. 265°-270° C.

Workup

  1. filtrationthe precipitate filtered off
  2. washwashed with cold 6N hydrochloric acid
  3. customdried

Sources & evidence

ORD record
ord-c5f8d1cfcb224e08b8051b532a91ee86
Source dataset
uspto-grants-1988_08
Patent number
US04766127

Reaction notes

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