Sodium Bicarbonate → HCID 23700750, compound

HRID 35197Notes

Reaction equation

HRID 35197 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]([OH:20])=[O:19])[CH:14]=3)[CH:9]=2)[CH:2]=1.C(=O)(O)[O-].[Na+:25]>CO.O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]([O-:20])=[O:19])[CH:14]=3)[CH:9]=2)[CH:2]=1.[Na+:25]

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 15612245HCID 15612245, compound

Product 1

HCID 23700750HCID 23700750, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2-(3-pyridylmethyl)naphthalene-6-carboxylic acid is dissolved in methanol and to this solution a stoichiometric amount of sodium bicarbonate dissolved in water is added. The mixture is stirred at room temperature for one hour, azeotroped with benzene twice and dried under high vacuum for 3 hours. The solid material is recrystallized from methanol and diethyl ether mixture and dried in vacuum at room temperature overnight to give sodium 2-(3-pyridylmethyl)naphthalene-6-carboxylate.

Workup

  1. additionis added
  2. customazeotroped with benzene twice
  3. customdried under high vacuum for 3 hours
  4. customThe solid material is recrystallized from methanol and diethyl ether mixture
  5. customdried in vacuum at room temperature overnight

Sources & evidence

ORD record
ord-e4051285d2034c3fab13d34eea952d49
Source dataset
uspto-grants-1988_08
Patent number
US04766127

Reaction notes

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