Hydrogen Peroxide → HCID 178493598, compound

HRID 35198Notes

Reaction equation

HRID 35198 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N:18][CH:19]=[CH:20][CH:21]=2.[OH:23]O>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[NH:15][C:16]2[C:17]([N:22]=1)=[N+:18]([O-:23])[CH:19]=[CH:20][CH:21]=2

Participants

3

Reactant 2

HCID 784Hydrogen PeroxideHCID 13282053Phenol, 4-(1H-imidazo(4,5-b)pyridin-2-yl)-3-methoxy-, methanesulfonate (ester)

Product 1

HCID 178493598HCID 178493598, compound

Procedure

3.19 g of 2-(2-methoxy-4-methanesulfonyloxy-phenyl)imidazo[4,5-b]pyridine were dissolved in 25 ml of and then 5 ml of 30% hydrogen peroxide were added dropwise thereto. The mixture was refluxed for one hour and concentrated to about one-tenth of its volume. The residue was poured onto ice and digested until it had crystallized throughout. Yield: 2.1 g (63% of theory). Melting point: 110°-125° C.

Workup

  1. additionwere added dropwise
  2. temperatureThe mixture was refluxed for one hour
  3. concentrationconcentrated to about one-tenth of its volume
  4. additionThe residue was poured onto ice
  5. customhad crystallized throughout

Sources & evidence

ORD record
ord-d6d33bcd1b744be3bbafcc15bfa04e8e
Source dataset
uspto-grants-1988_08
Patent number
US04766130

Reaction notes

Loading…