Hydroxyamine hydrochloride → HCID 59071619, compound

HRID 351983Notes

Reaction equation

HRID 351983 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][N:17]3[C:21]4[CH2:22][CH2:23][CH2:24][N:25]([CH3:29])[S:26](=[O:28])(=[O:27])[C:20]=4[CH:19]=[CH:18]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:31][OH:32].C([O-])(=O)C.[Na+]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][N:17]3[C:21]4[C:22](=[N:31][OH:32])[CH2:23][CH2:24][N:25]([CH3:29])[S:26](=[O:28])(=[O:27])[C:20]=4[CH:19]=[CH:18]3)[CH2:12][CH2:13]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 22714957HCID 22714957, compound

Product 1

HCID 59071619HCID 59071619, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 174 mg (0.4 mmol) of Compound 26, 56 mg (0.8 mmol) of hydroxylamine hydrochloride and 66 mg (0.8 mmol) of sodium acetate in 20 ml of methanol was refluxed for 17 hours. Post-treatment and purification were conducted in a similar manner as in Example 20, whereby 119 mg of the title compound were obtained (yield: 66%).

Workup

  1. temperaturewas refluxed for 17 hours
  2. customPost-treatment and purification

Sources & evidence

ORD record
ord-781f109b87c84027a1fc300bac504f8b
Source dataset
uspto-grants-2004_06
Patent number
US06743913B2

Reaction notes

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