反应详情

4-(Trifluoromethyl)cinnamamide (1 g, 4.65 mmol) and 1,3-dichloroacetone (1.1 g, 8.66 mmol) were added to toluene (5 ml) and the mixture was refluxed under heating for 8 hours. Ethyl acetate (20 ml) was added, and the mixture was washed with water (20 ml) twice and concentrated under reduced pressure. To the residue was added methanol (4 ml) and the mixture was stirred at room temperature. The crystals were filtrated and dried under reduced pressure to give 4-(chloromethyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole (733 mg, yield 55%).

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 8 hours
3. washthe mixture was washed with water (20 ml) twice
4. concentrationconcentrated under reduced pressure
5. additionTo the residue was added methanol (4 ml)
6. filtrationThe crystals were filtrated
7. customdried under reduced pressure