3-(2,3alpha-Dihydro-13-nitro-6-n-propyl-8alpha-ergolinyl)-1,1-diethylurea → 3-(2,3alpha-Dihydro-6-methyl-13-nitro-8beta-ergolinyl)-1,1-diethylurea

HRID 35210Notes

Reaction equation

HRID 35210 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:19]3[C@@H:9]([CH2:10][C@@H:11]4[C@@H:16]([C:17]=3[CH:18]=1)[CH2:15][C@H:14]([NH:20][C:21](=[O:27])[N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[CH2:13][N:12]4[CH2:28]CC)[CH2:8][NH:7]2)([O-:3])=[O:2]>C(Cl)(Cl)Cl>[CH3:28][N:12]1[C@H:11]2[C@@H:16]([C:17]3[CH:18]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[C:6]4[C:19]=3[C@@H:9]([CH2:10]2)[CH2:8][NH:7]4)[CH2:15][C@@H:14]([NH:20][C:21](=[O:27])[N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[CH2:13]1

Participants

3

Reactant 1

HCID 867423463-(2,3alpha-Dihydro-13-nitro-6-n-propyl-8alpha-ergolinyl)-1,1-diethylurea

Product 1

HCID 867423453-(2,3alpha-Dihydro-6-methyl-13-nitro-8beta-ergolinyl)-1,1-diethylureaYield 50%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

3-(2,3α-Dihydro-13-nitro-6-n-propyl-8α-ergolinyl)-1,1-diethylurea. Yield: 50%. [α]D =-156° (0.5% in CHCl3).

Sources & evidence

ORD record
ord-9b40b7ba300a496684bbb24b03014956
Source dataset
uspto-grants-1988_08
Patent number
US04766128

Reaction notes

Loading…