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HRID35211

反应详情

EQUATION

反应方程式

HRID 35211 的结构方程式

REACTANTS

反应物

2
结构：O
HCID962

Water

H2O

结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3c([N+](=O)[O-])ccc4c3[C@H](C[C@H]2N(C)C1)CN4C(C)=O
HCID86742348

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3c([N+](=O)[O-])ccc4c3C(CN4)C[C@H]2N(C)C1
HCID86742347

未命名化合物

收率 59.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

结构：NN
溶剂HCID9321

Hydrazine

H4N2

PROCEDURE

实验过程

One millimole of 3-(1-acetyl-2,3β-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea is heated in a mixture of 2 ml of anhydrous hydrazine and 2 ml of chloroform for 3 hours to 50° C., poured into water, extracted with methylene chloride, the organic phase is dried, and evaporated under vacuum, yielding 230 mg of 3-(2,3-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea. Yield: 25%. [α]D =+538° (0.5% in methanol) as the tartaric acid salt.

WORKUP

后处理

  1. extractionextracted with methylene chloride
  2. customthe organic phase is dried
  3. customevaporated under vacuum