Water → 3-(2,3-Dihydro-6-methyl-12-nitro-8alpha-ergolinyl)-1,1-diethylurea

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Reaction Steps

One millimole of 3-(1-acetyl-2,3β-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea is heated in a mixture of 2 ml of anhydrous hydrazine and 2 ml of chloroform for 3 hours to 50° C., poured into water, extracted with methylene chloride, the organic phase is dried, and evaporated under vacuum, yielding 230 mg of 3-(2,3-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea. Yield: 25%. [α]D =+538° (0.5% in methanol) as the tartaric acid salt.

Provenance & Evidence