反应详情

2-[4-Chloro-1-(2,5-dichlorophenoxy)butyl]thiophene (2.4 g, 7.1 mmol) was dissolved in a saturated solution of sodium iodide in acetone (200 ml) and the reaction refluxed for 20 hours. The reaction mixture was cooled and the solid filtered off. The filtrate was evaporated in vacuo and the residue taken up in water (50 ml). The mixture was extracted with diethyl ether (3×70 ml) and the combined organic portions were washed with water (3×30 ml), dried (magnesium sulphate), filtered and evaporated in vacuo to give the title compound as a pale straw coloured oil (2.91 g, 95%).

1. temperaturethe reaction refluxed for 20 hours
2. temperatureThe reaction mixture was cooled
3. filtrationthe solid filtered off
4. customThe filtrate was evaporated in vacuo
5. extractionThe mixture was extracted with diethyl ether (3×70 ml)
6. washthe combined organic portions were washed with water (3×30 ml)
7. dry with materialdried (magnesium sulphate)
8. filtrationfiltered
9. customevaporated in vacuo