HCID 131724442, compound → HCID 88013403, compound

HRID 352114Notes

Reaction equation

HRID 352114 reaction equation
[CH3:1][C:2]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][CH2:10][C:11](=[N:16]O)[CH2:12][CH:13]([CH3:15])[CH3:14])([CH3:4])[CH3:3]>C(O)C.[Rh]>[CH3:3][C:2]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][CH2:10][CH:11]([NH2:16])[CH2:12][CH:13]([CH3:14])[CH3:15])([CH3:1])[CH3:4]

Participants

4

Reactant 1

HCID 131724442HCID 131724442, compound

Product 1

HCID 88013403HCID 88013403, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

A solution of E and Z isomers of 4-(hydroxyimino)-6-methylheptylcarbamic acid 1,1-dimethylethyl ester (2.1 g, 8.13 mmol) in ethanol (75 ml) was hydrogenated at 5 bar pressure over rhodium on alumina (200 mg) for 36 h. The mixture was then filtered and the filtrate concentrated to dryness to afford the title compound in quantitative yield (2 g).

Workup

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate concentrated to dryness

Sources & evidence

ORD record
ord-c0ebb5e571a944e1969b12920366795a
Source dataset
uspto-grants-2004_06
Patent number
US06743939B2

Reaction notes

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