反应详情

One millimole of 3-(1-acetyl-2,3-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea, dissolved in 5 ml of 1N hydrochloric acid, is heated for one hour to 95° C. After cooling, the mixture is made alkaline with dilute ammonia solution, combined with methylene chloride, and extracted. After drying the organic phase, the latter is evaporated, thus obtaining 220 mg of 3-(2,3-dihydro-6-methyl-12-nitro-8α-ergolinyl)-1,1-diethylurea.

1. temperatureis heated for one hour to 95° C
2. temperatureAfter cooling
3. extractionextracted
4. customAfter drying the organic phase
5. customthe latter is evaporated