huagongshe.com
HRID35213

反应详情

EQUATION

反应方程式

HRID 35213 的结构方程式

REACTANTS

反应物

1
结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc([N+](=O)[O-])cc4c3C(CN4)C[C@H]2N(C)C1
HCID86742343

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc([N+](=O)[O-])cc4[nH]cc(c34)C[C@H]2N(C)C1
HCID13374957

未命名化合物

收率 54.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

One millimole of 3-(2,3-dihydro-6-methyl-13-nitro-8α-ergolinyl)-1,1-diethylurea is dissolved in 10 ml of methylene chloride, and 2 g of pyrolusite in solid form is added thereto. The mixture is then stirred for 2 hours at room temperature. After removing excess pyrolusite by filtration, the filtrate is evaporated. The residue is chromatographed on silica gel with methylene chloride/methanol (5%), thus obtaining 210 mg of 3-(6-methyl-13-nitro-8α-ergolinyl)-1,1-diethylurea.

WORKUP

后处理

  1. customAfter removing excess pyrolusite
  2. filtrationby filtration
  3. customthe filtrate is evaporated
  4. customThe residue is chromatographed on silica gel with methylene chloride/methanol (5%)