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HRID35218

反应详情

EQUATION

反应方程式

HRID 35218 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：B.CSC
HCID12423031

未命名化合物

结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(N)cc4[nH]cc(c34)C[C@H]2N(C)C1
HCID86742358

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(NC)cc4[nH]cc(c34)C[C@H]2N(C)C1
HCID86742357

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=CO
溶剂HCID284

Formic acid

CH2O2

PROCEDURE

实验过程

At -20° C., 355 mg of 3-(13-amino-6-methyl-8α-ergolinyl)-1,1-diethylurea is reacted to the N-formyl compound with the mixed anhydride of acetic acid and formic acid and the N-formyl compound is reduced with borane-dimethyl sulfide (S. Krishnamurty, Tetrahedron Letters 1982: 3315). After chromatography, 260 mg of 1,1-diethyl-3-(6-methyl-13-methylamino-8α-ergolinyl)urea is obtained.