HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1,1-Diethyl-3-(6-methyl-13-methylamino-8alpha-ergolinyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Reactant | 3-(13-Amino-6-methyl-8alpha-ergolinyl)-1,1-diethylurea | HCID 86742358 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 1,1-Diethyl-3-(6-methyl-13-methylamino-8alpha-ergolinyl)urea | HCID 86742357 | — |
Reaction Steps
At -20° C., 355 mg of 3-(13-amino-6-methyl-8α-ergolinyl)-1,1-diethylurea is reacted to the N-formyl compound with the mixed anhydride of acetic acid and formic acid and the N-formyl compound is reduced with borane-dimethyl sulfide (S. Krishnamurty, Tetrahedron Letters 1982: 3315). After chromatography, 260 mg of 1,1-diethyl-3-(6-methyl-13-methylamino-8α-ergolinyl)urea is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766128 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-0b54ebb2001341259c7e0f254d3e5497 |
| Source note | uspto-grants-1988_08 |