反应详情

To a stirred solution of N-acetyl-3,4-dimethoxyphenethylamine (112.1 g, 0.502 m) in toluene (600 ml) maintained at 90°-95° was added dropwise phosphorusoxychloride (180.9 g, 112 ml, 1.179 mole) over a period of 1 hour. The mixture was heated to reflux for 2 hr, cooled to ambient temperature, and the solid hydrochloride salt collected by filtration, 170.4 g (wet with toluene). m.p. (after drying) 202°-203°.

1. temperatureThe mixture was heated
2. temperatureto reflux for 2 hr
3. filtrationthe solid hydrochloride salt collected by filtration, 170.4 g (wet with toluene)
4. custom(after drying) 202°-203°