HCID 69848080, compound → HCID 22713891, compound

HRID 352240Notes

Reaction equation

HRID 352240 reaction equation
C(OC(=O)[NH:7][CH:8]([C:16](=[O:40])[NH:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH:20]([N:24]2[C:33]3[CH:32]=[CH:31][CH:30]=[C:29]([Cl:34])[C:28]=3[C:27]3=[N:35][O:36][C:37]([CH3:38])=[C:26]3[C:25]2=[O:39])[CH2:19]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C>Cl>[NH2:7][CH:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:16]([NH:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH:20]([N:24]2[C:33]3[CH:32]=[CH:31][CH:30]=[C:29]([Cl:34])[C:28]=3[C:27]3=[N:35][O:36][C:37]([CH3:38])=[C:26]3[C:25]2=[O:39])[CH2:19]1)=[O:40]

Participants

3

Reactant 1

HCID 69848080HCID 69848080, compound

Product 1

HCID 22713891HCID 22713891, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of {1-[3-(9-chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester, 82 mg (0.14 mmol) in 15 mL of HCl-saturated acetic acid was stirred three hours at rt., then concentrated to dryness. The residue was slurried 3× in acetonitrile and concentrated to dryness to give a quantitative yield of the title compound as a tan foam. MS (ion spray) 479.2. (M+).

Workup

  1. concentration, then concentrated to dryness
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-8c0b2af5599a4baab93f1ee81ca5e17d
Source dataset
uspto-grants-2004_06
Patent number
US06743794B2

Reaction notes

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