Ethanol → HCID 22713803, compound

HRID 352244Notes

Reaction equation

[Cl:1][C:2]1[C:15]2[C:14]3[N:13]=[CH:12][CH:11]=[C:10](OC)C=3C(=O)[N:7]([CH:19]3[CH2:24][CH2:23][CH2:22][CH:21]([CH2:25][NH:26][C:27](=[O:34])[C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:20]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:35][NH2:36].[CH2:37]([OH:39])[CH3:38]>>[Cl:1][C:2]1[C:15]2[C:14]3[N:13]=[CH:12][CH:11]=[C:10]([NH:36][CH3:35])[C:38]=3[C:37](=[O:39])[N:7]([CH:19]3[CH2:24][CH2:23][CH2:22][CH:21]([CH2:25][NH:26][C:27](=[O:34])[C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:20]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 702Ethanol

HCID 6329Methylamine

HCID 22714138HCID 22714138, compound

Product 1

HCID 22713803HCID 22713803, compound

Procedure

To 0.005 g (0.01 mmols) of a compound from Example 696 was combined with 1.0 ml of aqueous methylamine 40% (excess) in ethanol (5 ml). The reaction was refluxed for 30 minutes. MS(ES+)m/z475.

Workup

temperatureThe reaction was refluxed for 30 minutes

Sources & evidence

ORD record: ord-404fca5af4404fca959b0b12214babe0
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06743794B2

Reaction notes

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